Title:
ＣＤＨ１９およびＣＤ３に対する抗体構築物
Document Type and Number:
Japanese Patent JP6522517
Kind Code:
B2
Abstract:
The present invention provides to an antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
Inventors:
Xiao Show Hoa
Panjen
Wycra Machine Gedineri
Jeffreys M. Shawn
King Chadwick Terence
Cham Bryan Mintan
Kufer Peter
Lutterby Ralph
Raum Tobias
Hoffman Patrick
Loudris
Kissel romance
Lemon brian
Weshe Oger
Panjen
Wycra Machine Gedineri
Jeffreys M. Shawn
King Chadwick Terence
Cham Bryan Mintan
Kufer Peter
Lutterby Ralph
Raum Tobias
Hoffman Patrick
Loudris
Kissel romance
Lemon brian
Weshe Oger
Application Number:
JP2015554186A
Publication Date:
May 29, 2019
Filing Date:
January 27, 2014
Export Citation:
Assignee:
AMGEN Research(Munich)GmbH
International Classes:
C07K16/46; A61K39/395; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/06; C12N15/13; C12N15/63; C12P21/08
Domestic Patent References:
| JP2008521411A | ||||
| JP2010524851A |
Other References:
ANTICANCER RESEARCH,2007年,vol.27,page. 3441-3450
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto