Title:
ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN ROR1 AND USE OF THE SAME
Document Type and Number:
Japanese Patent JP2021063058
Kind Code:
A
Abstract:
To provide a new antibody-drug conjugate targeting ROR1.SOLUTION: The present invention relates to an antibody conjugate of the general formula I defined by Ab-(X)y, or a pharmaceutically acceptable salt thereof. In the formula, Ab is an antibody or antigen-binding fragment thereof that specifically binds to the extracellular domain of ROR1, the antibody including a heavy chain variable region and a light chain variable region; X is a chemical residue which independently includes at least one active agent and a linker, where the linker links Ab and the at least one active agent; and y is an integer from 1 to 20.SELECTED DRAWING: None
Inventors:
PARK YUN HEE
SONG HO YEON
RYU HYUN MIN
KIM SUNG MIN
BAEK JU YUEL
OH JI HYE
HAN NARA
KIM HYOUNG RAE
PARK KYUNG EUN
LEE HYUN JUNG
LEE JU-YONG
KANG DAE HYUCK
YANG YOUNG-JAE
YOU JI-NA
KIM YONG ZU
LEE CHANG SUN
CHAE JEIWOOK
JUNG JINWON
KIM JUHEE
LEE BORA
SONG DAEHAE
SUNG BYUNGJE
YEOM DONGHOON
EOM JAEHYUN
HONG YOUNGEUN
AHN JINHYUNG
LEE YANGSOON
PARK KYUNGJIN
YOO JISEON
PARK MINJI
SONG HO YEON
RYU HYUN MIN
KIM SUNG MIN
BAEK JU YUEL
OH JI HYE
HAN NARA
KIM HYOUNG RAE
PARK KYUNG EUN
LEE HYUN JUNG
LEE JU-YONG
KANG DAE HYUCK
YANG YOUNG-JAE
YOU JI-NA
KIM YONG ZU
LEE CHANG SUN
CHAE JEIWOOK
JUNG JINWON
KIM JUHEE
LEE BORA
SONG DAEHAE
SUNG BYUNGJE
YEOM DONGHOON
EOM JAEHYUN
HONG YOUNGEUN
AHN JINHYUNG
LEE YANGSOON
PARK KYUNGJIN
YOO JISEON
PARK MINJI
Application Number:
JP2020143359A
Publication Date:
April 22, 2021
Filing Date:
August 27, 2020
Export Citation:
Assignee:
LEGOCHEM BIOSCIENCES INC
ABL BIO INC
ABL BIO INC
International Classes:
C07K16/30; A61K31/5513; A61K39/395; A61K45/00; A61K45/06; A61K47/68; A61P35/00; A61P35/02; A61P43/00; C07K16/46
Attorney, Agent or Firm:
Hiraki International Patent Office