Title:
ANTIBODY-DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEIN
Document Type and Number:
Japanese Patent JP2019031563
Kind Code:
A
Abstract:
To provide antibody-drug conjugates (ADC) that bind to 191P4D12 protein and its variants for treating cancer.SOLUTION: Provided is an anti-191P4D12 antibody or antigen binding fragment thereof comprising a heavy chain variable region and a light chain variable region, where the heavy chain variable region comprises a heavy chain variable region complementarity determining region (CDR) of a specific amino acid sequence, and the light chain variable region comprises a light chain CDR of a specified amino acid sequence. The antibody or antigen-binding fragment thereof may be conjugated to a cytotoxic agent.SELECTED DRAWING: None
Inventors:
DAULET SATPAEV
MORRISON ROBERT KENDALL
MORRISON KAREN JANE MEYRICK
GUDAS JEAN
JAKOBOVITS AYA
MICHAEL TORGOV
AN ZILI
MORRISON ROBERT KENDALL
MORRISON KAREN JANE MEYRICK
GUDAS JEAN
JAKOBOVITS AYA
MICHAEL TORGOV
AN ZILI
Application Number:
JP2018207295A
Publication Date:
February 28, 2019
Filing Date:
November 02, 2018
Export Citation:
Assignee:
AGENSYS INC
SEATTLE GENETICS INC
SEATTLE GENETICS INC
International Classes:
C07K16/30; A61K38/08; A61K39/395; A61K41/00; A61K45/00; A61K47/68; A61P35/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Ryuichi Inoue
Koichi Niimi
Tomohiko Kobayashi
Toshi Gobe
Ryuichi Inoue
Koichi Niimi
Tomohiko Kobayashi