Title:
ANTIBODY FOR FACTOR XA INHIBITOR AND METHOD FOR USING THE SAME
Document Type and Number:
Japanese Patent JP2020109113
Kind Code:
A
Abstract:
To provide an antibody for factor xa inhibitor and method for using the same.SOLUTION: One of the major limitations of anticoagulant therapy is the limitation of the ability to rapidly reverse anticoagulant activity in the case of treatment-related bleeding risk and in cases of overdosage or required emergency surgical intervention. Therefore, a specific effective antidote for all forms of anticoagulant therapy is highly desirable. The present invention relates to an antidote to an anticoagulant that targets factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives described herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.SELECTED DRAWING: None
Inventors:
LU GENMIN
DAVID R PHILLIPS
PATRICK ANDRE
UMA SINHA
DAVID R PHILLIPS
PATRICK ANDRE
UMA SINHA
Application Number:
JP2020042919A
Publication Date:
July 16, 2020
Filing Date:
March 12, 2020
Export Citation:
Assignee:
PORTOLA PHARM INC
International Classes:
A61K38/43; A61K38/02; A61K38/36; A61K38/48; A61K39/395; A61K47/54; A61K47/60; A61K47/64; A61K47/66; A61K47/69; A61P7/04; C07K14/745; C07K16/36; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; A61K39/00
Domestic Patent References:
| JPH10502351A | 1998-03-03 | |||
| JPH06503950A | 1994-05-12 | |||
| JPH04505765A | 1992-10-08 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita