Title:
ANTIBODY FORMULATION AND METHOD
Document Type and Number:
Japanese Patent JP2023116817
Kind Code:
A
Abstract:
To provide an antibody formulation and a method.SOLUTION: The present invention provides, for example, a pharmaceutical formulation which comprises: (a) a chimeric or humanized version of antibody 2A4 (ATCC Accession Number PTA-9662) or of antibody 7D8 (ATCC Accession Number PTA-9468), or fragment thereof, which specifically competes for binding to antigen with 2A4 or 7D8, in which the antibody is present at a concentration within the range from about 1 mg/mL to about 100 mg/mL; (b) a histidine buffer present at a concentration within the range from about 20 mM to about 30 mM; (c) trehalose present at a concentration within the range from about 210 mM to about 250 mM; and (d) polysorbate 20 present at a concentration within the range from about 0.005 wt% to about 0.05 wt%; with a pH within the range from about 6 to about 7.SELECTED DRAWING: None
Inventors:
PATRICK GARIDEL
ISAAC CRAIG HENDERSON
PAMELA KLEIN
ISAAC CRAIG HENDERSON
PAMELA KLEIN
Application Number:
JP2023104081A
Publication Date:
August 22, 2023
Filing Date:
June 26, 2023
Export Citation:
Assignee:
PROTHENA BIOSCIENCES LTD
International Classes:
A61K39/395; A61K9/08; A61K9/19; A61K31/198; A61K31/454; A61K31/5375; A61K31/69; A61K47/18; A61K47/26; A61P7/00; A61P35/00; A61P39/02; A61P43/00; C07K16/18; C07K16/46; C12N5/10; C12N15/13; C12N15/63; C12P21/08
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto