Title:
ANTICANCER AGENT BINDING NUCLEIC-ACID APTAMER, AND UTILIZATION OF THE SAME
Document Type and Number:
Japanese Patent JP2013040118
Kind Code:
A
Abstract:
To provide a nucleic-acid aptamer which has camptothecins binding property.
The camptothecins binder is composed of a nucleic-acid aptamer including: arrangement of the following (i) or (ii); any arrangement with base No. 21 to 50 of either of arrangement No. 28 to 32, 35 to 43 and 45 to 59; arrangement with base No. 21 to 51 of arrangement No. 44; or arrangement with base No. 21 to 48 of arrangement No. 60; wherein (i) is GGGNGGGNGGGNGGG (Arrangement No.1) and (ii) is GGGNGGGNGGGNNGGG (Arrangement No.2).
Inventors:
KUWABARA MASAYASU
Application Number:
JP2011177072A
Publication Date:
February 28, 2013
Filing Date:
August 12, 2011
Export Citation:
Assignee:
UNIV GUNMA
International Classes:
A61K31/4745; A61K47/24; A61P35/00; C12N15/09
Domestic Patent References:
| JP2007056001A | 2007-03-08 | |||
| JP2007056001A | 2007-03-08 |
Foreign References:
| WO2011019031A1 | 2011-02-17 | |||
| WO2011019031A1 | 2011-02-17 |
Other References:
JPN6015022867; ＡＳＴＲＯＭ，Ｈ． ｅｔ ａｌ: 'Ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ ｂａｓｅｄ ａｒｔｉｆｉｃｉａｌ ｎｕｃｌｅａｓｅ （ＯＢＡＮ） ｓｙｓｔｅｍｓ． Ｂｕｌｇｅ ｓｉｚｅ ｄｅｐｅｎｄｅｎｃｅ ａｎｄ ｐｏｓｉｔｉｏｎｉｎｇ ｏｆ ｃ' Ｏｒｇａｎｉｃ ＆ Ｂｉｏｍｏｌｅｃｕｌａｒ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１， Ｎｏ．９, 2003, ｐ．１４６１-１４６５
JPN6015022868; ＡＤＡＭＣＺＹＫ，Ｍ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｈａｐｔｅｎ-ｐｈｏｓｐｈｏｒａｍｉｄｉｔｅｓ ｆｒｏｍ ２'-ｄｅｏｘｙｕｒｉｄｉｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５９， Ｎｏ．３０, 2003, ｐ．５７４９-５７６１
JPN7015001582; 桑原正靖: '人工核酸を用いたポリメラーゼ反応と人工核酸アプタマーの創製' 生化学 第８２巻， 第４号, 2010, 第３１８-３２３頁
JPN6015022871; ＩＭＡＩＺＵＭＩ，Ｙ． ｅｔ ａｌ: 'Ｅｆｆｉｃａｃｙ ｏｆ Ｂａｓｅ-Ｍｏｄｉｆｉｃａｔｉｏｎ ｏｎ Ｔａｒｇｅｔ Ｂｉｎｄｉｎｇ ｏｆ Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ ＤＮＡ Ａｐｔａｍｅｒｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１３５， Ｎｏ．２５, 2013, ｐ．９４１２-９４１９
JPN6015022867; ＡＳＴＲＯＭ，Ｈ． ｅｔ ａｌ: 'Ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ ｂａｓｅｄ ａｒｔｉｆｉｃｉａｌ ｎｕｃｌｅａｓｅ （ＯＢＡＮ） ｓｙｓｔｅｍｓ． Ｂｕｌｇｅ ｓｉｚｅ ｄｅｐｅｎｄｅｎｃｅ ａｎｄ ｐｏｓｉｔｉｏｎｉｎｇ ｏｆ ｃ' Ｏｒｇａｎｉｃ ＆ Ｂｉｏｍｏｌｅｃｕｌａｒ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１， Ｎｏ．９, 2003, ｐ．１４６１-１４６５
JPN6015022868; ＡＤＡＭＣＺＹＫ，Ｍ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｈａｐｔｅｎ-ｐｈｏｓｐｈｏｒａｍｉｄｉｔｅｓ ｆｒｏｍ ２'-ｄｅｏｘｙｕｒｉｄｉｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５９， Ｎｏ．３０, 2003, ｐ．５７４９-５７６１
JPN7015001582; 桑原正靖: '人工核酸を用いたポリメラーゼ反応と人工核酸アプタマーの創製' 生化学 第８２巻， 第４号, 2010, 第３１８-３２３頁
JPN6015022871; ＩＭＡＩＺＵＭＩ，Ｙ． ｅｔ ａｌ: 'Ｅｆｆｉｃａｃｙ ｏｆ Ｂａｓｅ-Ｍｏｄｉｆｉｃａｔｉｏｎ ｏｎ Ｔａｒｇｅｔ Ｂｉｎｄｉｎｇ ｏｆ Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ ＤＮＡ Ａｐｔａｍｅｒｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１３５， Ｎｏ．２５, 2013, ｐ．９４１２-９４１９
JPN6015022868; ＡＤＡＭＣＺＹＫ，Ｍ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｈａｐｔｅｎ-ｐｈｏｓｐｈｏｒａｍｉｄｉｔｅｓ ｆｒｏｍ ２'-ｄｅｏｘｙｕｒｉｄｉｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５９， Ｎｏ．３０, 2003, ｐ．５７４９-５７６１
JPN7015001582; 桑原正靖: '人工核酸を用いたポリメラーゼ反応と人工核酸アプタマーの創製' 生化学 第８２巻， 第４号, 2010, 第３１８-３２３頁
JPN6015022871; ＩＭＡＩＺＵＭＩ，Ｙ． ｅｔ ａｌ: 'Ｅｆｆｉｃａｃｙ ｏｆ Ｂａｓｅ-Ｍｏｄｉｆｉｃａｔｉｏｎ ｏｎ Ｔａｒｇｅｔ Ｂｉｎｄｉｎｇ ｏｆ Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ ＤＮＡ Ａｐｔａｍｅｒｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１３５， Ｎｏ．２５, 2013, ｐ．９４１２-９４１９
JPN6015022867; ＡＳＴＲＯＭ，Ｈ． ｅｔ ａｌ: 'Ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ ｂａｓｅｄ ａｒｔｉｆｉｃｉａｌ ｎｕｃｌｅａｓｅ （ＯＢＡＮ） ｓｙｓｔｅｍｓ． Ｂｕｌｇｅ ｓｉｚｅ ｄｅｐｅｎｄｅｎｃｅ ａｎｄ ｐｏｓｉｔｉｏｎｉｎｇ ｏｆ ｃ' Ｏｒｇａｎｉｃ ＆ Ｂｉｏｍｏｌｅｃｕｌａｒ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１， Ｎｏ．９, 2003, ｐ．１４６１-１４６５
JPN6015022868; ＡＤＡＭＣＺＹＫ，Ｍ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｈａｐｔｅｎ-ｐｈｏｓｐｈｏｒａｍｉｄｉｔｅｓ ｆｒｏｍ ２'-ｄｅｏｘｙｕｒｉｄｉｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５９， Ｎｏ．３０, 2003, ｐ．５７４９-５７６１
JPN7015001582; 桑原正靖: '人工核酸を用いたポリメラーゼ反応と人工核酸アプタマーの創製' 生化学 第８２巻， 第４号, 2010, 第３１８-３２３頁
JPN6015022871; ＩＭＡＩＺＵＭＩ，Ｙ． ｅｔ ａｌ: 'Ｅｆｆｉｃａｃｙ ｏｆ Ｂａｓｅ-Ｍｏｄｉｆｉｃａｔｉｏｎ ｏｎ Ｔａｒｇｅｔ Ｂｉｎｄｉｎｇ ｏｆ Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ ＤＮＡ Ａｐｔａｍｅｒｓ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１３５， Ｎｏ．２５, 2013, ｐ．９４１２-９４１９
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Shinichi Sanuki
Hidemi Matsukura
Shinichi Sanuki