Title:
抗葉酸受容体アルファ抗体の糖型
Document Type and Number:
Japanese Patent JP2014505012
Kind Code:
A
Abstract:
The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti-FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an anti-FRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention.
Inventors:
Sass, Philip M.
Nicolaides, Nicholas
Grasso, Luigi
Rosier, eric
Goo, way
Jan, Jason
Yao, Jun
Nicolaides, Nicholas
Grasso, Luigi
Rosier, eric
Goo, way
Jan, Jason
Yao, Jun
Application Number:
JP2013535058A
Publication Date:
February 27, 2014
Filing Date:
October 19, 2011
Export Citation:
Assignee:
Morphotech, Incorporated
International Classes:
C07K16/28; A61K39/395; A61P35/00; A61P35/02; A61P43/00; C12N5/10; C12N15/09; C12Q1/02; G01N33/53; G01N33/574; G01N33/577; C12P21/08; C12R1/91
Domestic Patent References:
| JP2008500025A | 2008-01-10 | |||
| JP2009521206A | 2009-06-04 |
Other References:
CLIN. CANCER RES., vol. 16, no. 21, JPN6015035305, September 2010 (2010-09-01), pages 5288 - 5295, ISSN: 0003148329
GLYCOBIOLOGY, vol. 19, no. 9, JPN6015035306, 2009, pages 936 - 949, ISSN: 0003148330
PHARMACEUTICALS, vol. 3, JPN6015035308, January 2010 (2010-01-01), pages 146 - 157, ISSN: 0003148331
BIOTECHNOL. PROG., vol. 21, JPN6015035309, 2005, pages 1 - 16, ISSN: 0003148332
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 5, JPN6015035310, 2003, pages 3466 - 3473, ISSN: 0003148333
GLYCOBIOLOGY, vol. 19, no. 9, JPN6015035306, 2009, pages 936 - 949, ISSN: 0003148330
PHARMACEUTICALS, vol. 3, JPN6015035308, January 2010 (2010-01-01), pages 146 - 157, ISSN: 0003148331
BIOTECHNOL. PROG., vol. 21, JPN6015035309, 2005, pages 1 - 16, ISSN: 0003148332
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 5, JPN6015035310, 2003, pages 3466 - 3473, ISSN: 0003148333
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto