ANTIGEN-BINDING MOLECULE AND LIBRARY THEREOF WHOSE ANTIGEN-BINDING ABILITY CHANGES DEPENDENTLY ON CONCENTRATION OF COMPOUNDS

Japanese Patent JP2022115883

A

To provide an antigen-binding molecule specific to a target tissue, an antigen-binding molecule whose antigen-binding activity changes dependently on concentration of an unnatural compounds, a library including a plurality of different antigen-binding molecules, a pharmaceutical composition containing the antigen-binding molecule, a method for screening the antigen-binding molecule, a producing method thereof, and like.SOLUTION: It was found that above problem may be solved by generating an antigen-binding domain or an antigen-binding molecule comprising the antigen-binding domain whose binding activity to an antigen changes dependently on concentration of low-molecular-weight compounds, creating a plurality of different antigen-binding domains and a library including the antigen-binding domains, and using the library. By using the antigen-binding molecule of the present invention, various diseases caused by target tissue can be treated specifically for the target tissue.SELECTED DRAWING: None

IGAWA TOMOYUKI
TANBA SHIGERO
SHIMIZU SHUN
TATSUMI KANAKO
KADONO SHOJIRO
KAWACHI HIROKI
OHARA KAZUHIRO
MATSUSHITA MASAYUKI
EMURA TAKESHI
KAMIMURA MASAKI

JP2022071294A

August 09, 2022

April 25, 2022

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CHUGAI PHARMACEUT CO LTD

C40B40/10; A61K39/39; A61K39/395; A61K48/00; A61P35/00; A61P37/04; C07K16/00; C12N15/13; C12P21/08; C40B40/08

Masao Haruna
Shimizu Hatsushi
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto

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