Title:
抗原コンジュゲート及びその使用
Document Type and Number:
Japanese Patent JP2008543810
Kind Code:
A
Abstract:
The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
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Inventors:
Bachmann, Martin
Alan Tissot
Jägerlener, Andrea
Philip, Saudan
Elephant, you
Schmitz, Nicole
Hoover, Adrian
Martin, Stephen
Hinton, Heather
Alan Tissot
Jägerlener, Andrea
Philip, Saudan
Elephant, you
Schmitz, Nicole
Hoover, Adrian
Martin, Stephen
Hinton, Heather
Application Number:
JP2008516309A
Publication Date:
December 04, 2008
Filing Date:
June 14, 2006
Export Citation:
Assignee:
Sights Biotechnology AG
International Classes:
A61K39/00; A61P19/02; A61P31/18; A61P35/00; C07K14/47; C07K14/595; C07K14/705; C07K14/715; C12N15/09
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori