Title:
ANTIINFLAMMATORY MEDICINAL COMPOSITION FOR LOCAL ADMINISTRATION
Document Type and Number:
Japanese Patent JPS62230721
Kind Code:
A
Abstract:
Compsn. for topical admin. comprises as active ingredient N-(2-(2-hydroxy-3-phenoxypropyl) aminoethyl)isobutyramide, having the formula (I) in racemic (R,S) or laevorotatory optically active (S) form, or an acid-addition salt of such a cpd., together with a suitable diluent or carrier. - The (S)-form of cpd. (I), or a salt of this form apart from the oxalate or 2,3:4,6-di-O-isopropylidene -alpha-D-xylo-hexulosofuranos onate salt, are new. (I) and the excluded salts are described in G.B. Pat. No. 1455116. The pref. active ingredient is the (S) form of (I) and its salts e.g. the hydrochloride, hydrobromide, citrate and D-gluconate. The compsn. may take the form e.g. of an ointment, cream, gel, salve, lotion, spray or aerosol, and may contain e.g. 0.1-5 wt.% of active ingredient. It may contain other active ingredients, esp. topically active steroids. A dispenser e.g. a deformable tube, may contain e.g. 5-250g of the compsn. - To prepare the (S) form of (I), the may be reacted with N-(2-aminoethyl)isobutyramide.
Inventors:
TOOMASU JIYAN ANDORUU BIRUSUKI
RARUFU HAU
BARUBAA SHINGU RAO
DEBUITSUDO SAMAAZU TOMUSON
RARUFU HAU
BARUBAA SHINGU RAO
DEBUITSUDO SAMAAZU TOMUSON
Application Number:
JP6927887A
Publication Date:
October 09, 1987
Filing Date:
March 25, 1987
Export Citation:
Assignee:
ICI PLC
International Classes:
A61K31/16; A61K31/165; A61P17/00; A61P29/00; A61K; (IPC1-7): A61K31/165; C07C103/44
Attorney, Agent or Firm:
Toshio Yano