Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANTIMOUSE TRAIL MONOCLONAL ANTIBODY
Document Type and Number:
Japanese Patent JP3585399
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To provide an antimouse TRAIL monoclonal antibody that can simply and exactly analyze in vitro or in vivo physiological functions other than the TRAIL development induction mechanism and the target cell breaking mechanism.
SOLUTION: Mouse B lymphoma 2PK-3 cell is prepared by transfecting the cell with the cDNA of mouse TRAIL, and the rat spleen cell immunized with the 2PK-3 cell and mouse myeloma cell are cell-fused to prepare a hybridoma. The hybridoma is cultured to produce the objective antimouse TRAIL monoclonal antibody that specifically binds to the mouse-originating TRAIL without cross reaction with Fas or TNF and completely inhibits the cytotoxic activity of TRAIL.


More Like This:
JPS5832958[Title of the Invention] A protoplast formation method of Strept married-woman Genus
JPH04501055[Title of the Invention] A monoclonal antibody for preventing infection by HIV ―Virus of a cell
WO/1984/004458MONOCLONAL ANTIBODIES REACTIVE WITH ENDOTOXIN CORE
Inventors:
Yasushi Okumura
Hideo Yagida
Nobuhiko Kagaki
Application Number:
JP21776399A
Publication Date:
November 04, 2004
Filing Date:
July 30, 1999
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Japan Science and Technology Agency
International Classes:
C12N15/02; C07K14/52; C07K16/24; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/02; G01N33/53; G01N33/577; C12R1/91; (IPC1-7): C12P21/08; C07K14/52; C07K16/24; C12N5/10; C12N15/02; C12N15/09; C12P21/02; C12Q1/02; G01N33/53; G01N33/577
Domestic Patent References:
JP11508445A
Other References:
J Immunol. ,1999年 3月 1日,Vol.162, No.5,p.2639-2647
J Biol Chem. ,1996年 5月31日,Vol.271, No.22, p.12687-12690
Attorney, Agent or Firm:
Masaki Hirota



 
Previous Patent: MANHOLE STEEL LID STRUCTURE

Next Patent: MOVING PICTURE EDITING AND BROWSING DEVICE