Title:
ミトコンドリアを標的とする抗酸化剤
Document Type and Number:
Japanese Patent JP2005535696
Kind Code:
A
Abstract:
The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.
Inventors:
Murphy, Michael, Pee.
Smith, Robin, A. Jay.
Smith, Robin, A. Jay.
Application Number:
JP2004527016A
Publication Date:
November 24, 2005
Filing Date:
August 05, 2003
Export Citation:
Assignee:
Medical Research Council
University of Otago
University of Otago
International Classes:
C07D293/06; A61K31/555; A61K31/662; A61K47/48; A61P3/10; A61P9/00; A61P25/00; A61P25/16; A61P29/00; A61P37/06; A61P39/06; C07D293/12; C07F9/547; C07F9/58; C07F9/6539; C07F13/00; (IPC1-7): C07F9/547; A61K31/662; A61P3/10; A61P9/00; A61P25/00; A61P25/16; A61P29/00; A61P37/06; A61P39/06; C07D293/06
Domestic Patent References:
| JPH10330355A | 1998-12-15 | |||
| JPH05117126A | 1993-05-14 | |||
| JPH10330355A | 1998-12-15 | |||
| JPH05117126A | 1993-05-14 |
Other References:
JPN6009039867, ＯＳＡＪＤＡ，Ｍ． ｅｔ ａｌ, "Ｂｉｓｂｅｎｚｉｓｏｓｅｌｅｎａｚｏｌ−３（２Ｈ）−ｏｎｅｓ， ａ ｎｅｗ ｇｒｏｕｐ ｏｆ ｅｂｓｅｌｅｎ ａｎａｌｏｇｕｅｓ", Ｐｏｌｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ, 2001, Ｖｏｌ．７５， Ｎｏ．６, ｐ．８２３−８３０
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ai Fujii
Ishii Teiji
Satoshi Fujita
Ai Fujii