NEW MATERIAL: A compound of formula I [one or two carbon atoms of the CH2 groups in formula II may be substituted with an alkyl or an alkoxy, or two carbon atoms of the CH2 groups may be bridged with an alkanediyl; (m) and (n) are each 1-4, and the sum is 3-5; R1 is H, an alkyl, a halo, OH, CF3, etc.; R2 and R3 are each H or an alkyl; Alk is an alkanediyl; R4 and R5 are each H, an alkyl or a halo; Het is formulae III-V (R6 is H, an alkyl, an aryl, NH2, etc.; R4 is H, an alkyl, a cycloalkyl, etc.), etc.], or its acid addition salt or stereochemically isomeric form.
EXAMPLE: 3-[4-[2-[4-(3-Ethyl-1,2,4-oxadiazol-5-yl)phenoxy]ethyl]-1-piperidinyl]-6- methylpyridazine.
USE: An antipicornaviral agent.
PROCESS: For example, an amine of formula VI is subjected to N-alkylation with a pyridazine of formula VII (W is a reactive eliminable group) optionally in an inert solvent to give the compound of formula I.
MARUSERU GEREBERUNUSU MARIA RU
GIRUBAATO AASAA JIYUURUZU GURA
SHIRIERU ARUFUONSU MARIA BAN D
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