Title:
副作用を減じたアンチセンス核酸
Document Type and Number:
Japanese Patent JP7128517
Kind Code:
B2
Abstract:
The present invention addresses the problem of providing an antisense oligonucleotide (ASO) with reduced side effects. To solve this problem, provided is an ASO having a structure, wherein phosphodiester bonds occurring naturally between oligonucleotides and phosphorothioate bonds obtained by substituting one of oxygen atoms in a phosphate group by a sulfur atom are alternately positioned, as an antisense activity site.
Inventors:
Junichi Yano
Manaki Tanigawara
Manaki Tanigawara
Application Number:
JP2018539601A
Publication Date:
August 31, 2022
Filing Date:
August 25, 2017
Export Citation:
Assignee:
Rena Therapeutics Co., Ltd.
International Classes:
C12N15/113; A61K31/712; A61K31/7125; A61K31/713; A61K48/00; A61P35/00; C12N15/10
Domestic Patent References:
| JP9506248A | ||||
| JP2016509837A |
Foreign References:
| WO2000003720A1 | ||||
| US20090203896 | ||||
| WO1999050409A1 | ||||
| WO2015017675A2 |
Other References:
ZHOU W. et al,Bioorganic & Medicinal Chemistry Letters,1998年,8,p.3269-3274
SCHMAJUK G. et al,J. Biol. Chem.,1999年,Vol.274, No.31,pp.21783-21789
PATIL S.V. et al,Bioorganic & Medicinal Chemistry Letters,1994年,Vol.4, No.22,pp.2663-2666
LI Song et al,Pharmaceutical Research,1998年,Vol.15 No.10,p.1540-1545
JEONG J.H. et al,J. Biomater. Sci. Polymer Edn,2005年,Vol.16 No.11,pp.1409-1419
KURRECK J. et al.,Nucleic Acids Research,2002年,Vol.30 No.9,p.1911-1918
SCHMAJUK G. et al,J. Biol. Chem.,1999年,Vol.274, No.31,pp.21783-21789
PATIL S.V. et al,Bioorganic & Medicinal Chemistry Letters,1994年,Vol.4, No.22,pp.2663-2666
LI Song et al,Pharmaceutical Research,1998年,Vol.15 No.10,p.1540-1545
JEONG J.H. et al,J. Biomater. Sci. Polymer Edn,2005年,Vol.16 No.11,pp.1409-1419
KURRECK J. et al.,Nucleic Acids Research,2002年,Vol.30 No.9,p.1911-1918
Attorney, Agent or Firm:
Esaki Mitsufumi
Blacksmith Minoru Sawa
Katsuri Uenishi
Ichiro Torayama
Blacksmith Minoru Sawa
Katsuri Uenishi
Ichiro Torayama