Title:
抗腫瘍活性2-置換D-ホモエストラ-1,3,5(10)-トリエン-3-イルスルファメート
Document Type and Number:
Japanese Patent JP4718439
Kind Code:
B2
Abstract:
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, which can be influenced positively by the inhibition of tubulin polymerization. The compounds according to the invention are distinguished by a D-homo-substitution. They have a special action with respect to tubulin polymerization inhibition and can be used, for example, for treating prostate cancer
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Inventors:
Hirish, alexander
Peters, Olaf
Gege, Christian
G-Meister, Gerhard
Unger, Eberhard
Peters, Olaf
Gege, Christian
G-Meister, Gerhard
Unger, Eberhard
Application Number:
JP2006501900A
Publication Date:
July 06, 2011
Filing Date:
February 19, 2004
Export Citation:
Assignee:
Sterix limited
International Classes:
C07J63/00; A61K31/56; A61K31/565; A61K31/567; A61P35/00; A61P43/00; C07J31/00; C07J41/00
Domestic Patent References:
| JP2001527089A | ||||
| JP2001524524A | ||||
| JP2001525855A | ||||
| JP57116100A |
Foreign References:
| US6046186 | ||||
| WO2001030803A1 |
Other References:
MACCARTHY-MORROGH L,CANCER RESEARCH,米国,AMERICAN ASSOCIATION FOR CANCER RESEARCH,2000年10月 1日,V60 N19,P5441-5450
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Kazumi Nakamura