Title:
抗腫瘍作用増強剤
Document Type and Number:
Japanese Patent JP5000831
Kind Code:
B2
Abstract:
When used concurrently with an antitumor agent, a compound having a Rho kinase inhibitory activity, such as (R)-(+)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide, reinforces an antitumor effect of the antitumor agent and is useful as an antitumor effect potentiator. Particularly, a compound having a Rho kinase inhibitory activity used with an antitumor agent in combination can reduce the dose of the antitumor agent, which in turn affords provision of a sufficient effect and/or reduction of side effects.
Inventors:
Akihiro Fujii
Hiroshi Tanaka
Makio Otsuki
Takashi Kawaguchi
Koichi Oshita
Hiroshi Tanaka
Makio Otsuki
Takashi Kawaguchi
Koichi Oshita
Application Number:
JP2002503333A
Publication Date:
August 15, 2012
Filing Date:
June 22, 2001
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
International Classes:
A61K31/4409; A61K31/27; A61K31/335; A61K31/337; A61K31/415; A61K31/437; A61K31/4375; A61K31/44; A61K31/4402; A61K31/4406; A61K31/444; A61K31/4453; A61K31/4545; A61K31/50; A61K31/501; A61K31/505; A61K31/519; A61K31/7048; A61K33/243; A61K45/06; A61P35/00; A61P43/00
Domestic Patent References:
| JPH10113187A | 1998-05-06 | |||
| JPH10201480A | 1998-08-04 |
Foreign References:
| WO1998006433A1 | 1998-02-19 |
Attorney, Agent or Firm:
Takashima Ichi