Title:
ANTIVIRAL SUBSTITUTED 1,3-OXATHIOLANE
Document Type and Number:
Japanese Patent JP3105154
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject new compound capable of readily synthesizing a low toxic effective anti-HIV compound.
SOLUTION: This 1,3-oxathiolane is represented by formula I [R1 is H; Z is S, S=O or SO2; R2 is represented by the formula (R3 is H or a 1-6C alkyl; R4 is H, hydroxymethyl or the like)], its geometric isomer and/or optical isomer, e.g. 2-benzoyloxymethyl-5-ethoxy-1,3-oxathiolane. The compound is obtained by reacting, e.g. a compound represented by formula III (R1 is H or an OH protecting group; L is an atom or a leaving group which can be replaced) with a compound represented by the formula R2-H, then as necessary, removing an optional protecting group and converting the resultant compound into a pharmaceutically acceptable salt.
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Inventors:
Bernard Bellow
Nye Nyen-Ba
Nye Nyen-Ba
Application Number:
JP20893695A
Publication Date:
October 30, 2000
Filing Date:
August 16, 1995
Export Citation:
Assignee:
Biochem Pharma Inc.
International Classes:
A61K31/39; A61K31/41; A61K31/42; A61K31/445; A61K31/495; A61K31/505; A61K31/506; A61K31/513; A61K31/519; A61K31/52; A61K31/522; A61K31/53; A61K31/54; C07D411/04; A61P31/12; A61P31/18; C07B53/00; C07D239/10; C07D239/36; C07D239/47; C07D239/54; C07D263/06; C07D327/04; C07D405/04; C07D411/02; C07D411/14; C07D473/00; C07D473/04; C07D473/16; C07D473/18; C07D473/28; C07D473/30; C07D473/32; C07D473/34; C07D473/40; C07D487/04; A61K; C07D; C07H; (IPC1-7): C07D411/04; A61K31/513; A61K31/52; A61K31/522; A61P31/18; C07D411/14; C07D473/16; C07D473/18; C07D473/32; C07D473/34; C07D473/40; C07D487/04
Domestic Patent References:
| JP5505794A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)