Title:
ＡｐｏＡ－１融合ポリペプチドならびに関連する組成物および方法
Document Type and Number:
Japanese Patent JP7233113
Kind Code:
B2
Abstract:
Compositions and methods relating to ApoA-1 fusion polypeptides are disclosed. The fusion polypeptides include a first polypeptide segment corresponding to an ApoA-1 polypeptide or ApoA-1 mimetic, and may also include a dimerizing domain such as, e.g., an Fc region, which is typically linked carboxyl-terminal to the first polypeptide segment via a flexible linker. In some embodiments, the fusion polypeptide further includes a second polypeptide segment located carboxyl-terminal to the first polypeptide segment and which confers a second biological activity (e.g., an RNase, paraoxonase, platelet-activating factor acetylhydrolase, cholesterol ester transfer protein, lecithin-cholesterol acyltransferase, polypeptide that specifically binds to proprotein convertase subtilisin/kexin type 9, or polypeptide that specifically binds to amyloid beta). Also disclosed are dimeric proteins comprising first and second ApoA-1 fusion polypeptides as disclosed herein. The fusion polypeptides and dimeric proteins are useful in methods for therapy.
Inventors:
Martha S. Heiden-Red Better
Jeffrey A. Red Better
Vince Montes
Jeffrey A. Red Better
Vince Montes
Application Number:
JP2020202324A
Publication Date:
March 06, 2023
Filing Date:
December 04, 2020
Export Citation:
Assignee:
Seripion, Incorporated
International Classes:
A61K38/16; C12N15/62; A61K38/17; A61K45/00; A61K47/65; A61K47/68; A61P1/16; A61P3/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/10; A61P13/12; A61P17/00; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P37/02; A61P37/06; A61P39/02; A61P43/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/02
Foreign References:
| US20110178029 | ||||
| US20040115183 | ||||
| US20140363428 |
Other References:
Database UniProt[online], Accession No.P02647, 2014-11-26 uploaded, [retrieved on 2020-08-28], , Definition: RecName: Full=Apolipoprotein A-I
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto