Title:
アポトーシスシグナル調節キナーゼ阻害剤
Document Type and Number:
Japanese Patent JP5745721
Kind Code:
B2
Abstract:
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
Inventors:
Corkey, Briton
Groop, michael
Coach, keith
Melvin, Lawrence S.
Notte, Gregory
Groop, michael
Coach, keith
Melvin, Lawrence S.
Notte, Gregory
Application Number:
JP2012520706A
Publication Date:
July 08, 2015
Filing Date:
July 12, 2010
Export Citation:
Assignee:
Gilead Sciences, Inc.
International Classes:
C07D401/12; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61P9/00; A61P25/00; A61P29/00; A61P37/06; A61P43/00; C07D401/14; C07D405/14; C07D417/14; C07D471/04; C07D491/048
Domestic Patent References:
| JP2008519850A | ||||
| JP11349572A | ||||
| JP2008524233A |
Foreign References:
| WO2001068585A1 | ||||
| EP2058309A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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