Title:
分化ポテンシャルを改変した多能性幹細胞の動物の作製への応用
Document Type and Number:
Japanese Patent JP7071749
Kind Code:
B2
Abstract:
The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.
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Inventors:
Keiko Nakauchi
Hideyuki Sato
Hideki Masaki
Watanabe
Hideyuki Sato
Hideki Masaki
Watanabe
Application Number:
JP2019548191A
Publication Date:
May 19, 2022
Filing Date:
October 09, 2018
Export Citation:
Assignee:
National University Corporation The University of Tokyo
International Classes:
C12N15/09; A01K67/027; C12N5/0735; C12N5/10
Foreign References:
| WO2006009297A1 |
Other References:
Rhinn M et al. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. Mar;125(5):845-56. PMID: 9449667.,1998年
Dondorp W, Johnson MH. Human-animal chimeras: circumventing rather than discussing ethical concerns comes at a price. Reprod Biomed Online. 35(4):341-342. doi: 10.1016/j.rbmo.2017.07.001. PMID: 28733170,2017年07月19日
Rashid T et al. Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras. Cell Stem Cell. 2014 Oct 2;15(4):406-409. doi: 10.1016/j.stem. PMID: 25280216.,2014年
Yamaji, M., Seki, Y., Kurimoto, K. et al. Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet 40, 1016-1022. https://doi.org/10.1038/ng.186,2008年
Dondorp W, Johnson MH. Human-animal chimeras: circumventing rather than discussing ethical concerns comes at a price. Reprod Biomed Online. 35(4):341-342. doi: 10.1016/j.rbmo.2017.07.001. PMID: 28733170,2017年07月19日
Rashid T et al. Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras. Cell Stem Cell. 2014 Oct 2;15(4):406-409. doi: 10.1016/j.stem. PMID: 25280216.,2014年
Yamaji, M., Seki, Y., Kurimoto, K. et al. Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet 40, 1016-1022. https://doi.org/10.1038/ng.186,2008年
Attorney, Agent or Firm:
Seiji Ohno
Yu Morita
Yu Morita
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