Title:
アプラマイシン誘導体
Document Type and Number:
Japanese Patent JP7313631
Kind Code:
B2
Abstract:
The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.
Inventors:
Bottger, Eric See
Hobby, Sven N
Andrea, Vasera
Clitch, david
Sonosi, Amur
Takayuki Kato
Kirke, Jonathan
Raja Sekaran, Paraslaman
Sarpe, Vikram Ashok
Hobby, Sven N
Andrea, Vasera
Clitch, david
Sonosi, Amur
Takayuki Kato
Kirke, Jonathan
Raja Sekaran, Paraslaman
Sarpe, Vikram Ashok
Application Number:
JP2019559820A
Publication Date:
July 25, 2023
Filing Date:
May 01, 2018
Export Citation:
Assignee:
Wayne State University
Univel Zite Zurich
Univel Zite Zurich
International Classes:
C07H15/232; A61K31/7048; A61P31/04
Domestic Patent References:
| JP2013537177A | ||||
| JP57072999A |
Foreign References:
| WO2017018528A1 |
Other References:
ABE,Y. et al.,Aminoglycoside antibiotics. XIV. Synthesis and activity of 6-O-(3-amino-3-deoxy-α-D-glucopyranosyl)- and 5-O-(β-D-ribofuranosyl)apramycins,Journal of Antibiotics,1981年,Vol.34, No.11,p.1434-46
GIRISH C SATI et al.,N6',N6''',AND O4'-MODIFICATIONS TO NEOMYCIN AFFECT RIBOSOMAL SELECTIVITY WITHOUT COMPROMISING ANTIBACTERIAL ACTIVITY,ACS INFECTIOUS DISEASES,2017年04月06日,Vol.3, No.5,p.1-24(368-377),http:doi.org/10.1021/acsinfecdis.6b00214
GIRISH C SATI et al.,N6',N6''',AND O4'-MODIFICATIONS TO NEOMYCIN AFFECT RIBOSOMAL SELECTIVITY WITHOUT COMPROMISING ANTIBACTERIAL ACTIVITY,ACS INFECTIOUS DISEASES,2017年04月06日,Vol.3, No.5,p.1-24(368-377),http:doi.org/10.1021/acsinfecdis.6b00214
Attorney, Agent or Firm:
Toshiaki Morimoto