Title:
APROTININ POLYPEPTIDE FOR TRANSPORTING COMPOUND THROUGH BLOOD BRAIN BARRIER
Document Type and Number:
Japanese Patent JP2014088386
Kind Code:
A
Abstract:
To provide improvement in the field of agent delivery; and a non-invasive and flexible method and carrier for transporting a compound or an agent through an individual blood brain barrier.
A biologically active polypeptide can cross a cell layer imitating a mammalian blood brain barrier in an in vitro assay, where the polypeptide may be selected from the group consisting of an aprotinin having a particular sequence, an aprotinin analog, an aprotinin fragment which may comprises an amino acid sequence defined in the sequence, a biologically active analog of the sequence, a biologically active fragment and a biologically active fragment of the analog.
Inventors:
BELIVEAU RICHARD
DEMEULE MICHEL
CHE CHRISTIAN
REGINA ANTHONY
DEMEULE MICHEL
CHE CHRISTIAN
REGINA ANTHONY
Application Number:
JP2013245690A
Publication Date:
May 15, 2014
Filing Date:
November 28, 2013
Export Citation:
Assignee:
ANGIOCHEM INC
International Classes:
C07K14/47; A61K31/196; A61K31/198; A61K31/337; A61K31/475; A61K31/675; A61K31/704; A61K31/7048; A61K39/395; A61K47/42; A61K47/48; A61K49/00; A61P9/10; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P35/00; A61P35/04; C12N9/99
Foreign References:
| WO2004060403A2 | 2004-07-22 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro