Title:
FPアゴニストとして有用な、芳香族のあるC16~C20が置換されたテトラヒドロプロスタグランジン類
Document Type and Number:
Japanese Patent JP4619531
Kind Code:
B2
Abstract:
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: wherein R1, R2, R3, R4, X, and Z are as defined. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using theses compounds or the compositions containing them.
Inventors:
Delong Mitchell Anthony
Wos John August
Amber Gay Jack S. Jr.
Debiswanus
Dai Haiyan George
Sopar David Lindsay
Wos John August
Amber Gay Jack S. Jr.
Debiswanus
Dai Haiyan George
Sopar David Lindsay
Application Number:
JP2000510710A
Publication Date:
January 26, 2011
Filing Date:
September 04, 1998
Export Citation:
Assignee:
DUKE UNIVERSITY
International Classes:
A61K31/5575; A61K31/557; C07C405/00; A61P19/08; A61P19/10; A61P27/06; A61P43/00; C07C59/11; C07C69/675; C07C229/28; C07C259/06; C07C317/06; C07C321/16
Domestic Patent References:
| JP58029710A | ||||
| JP52053841A | ||||
| JP51086449A | ||||
| JP49093342A | ||||
| JP7165703A | ||||
| JP6316525A | ||||
| JP1151552A |
Foreign References:
| WO1997023225A1 | ||||
| US5703108 |
Attorney, Agent or Firm:
Shigeyoshi
Fukamachi Miko
Yoshikazu Tani
Kazuo Abe
Fukamachi Miko
Yoshikazu Tani
Kazuo Abe