Title:
FPアゴニストとして有用な、芳香族のあるC16~C20が置換されたテトラヒドロプロスタグランジン類
Document Type and Number:
Japanese Patent JP5330324
Kind Code:
B2
Abstract:
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: wherein R1, R2, R3, R4, X, and Z are as defined. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using theses compounds or the compositions containing them.
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Inventors:
Delong Mitchell Anthony
Wos John August
Amber Gay Jack S. Jr.
Debiswanus
Dai Haiyan George
Sopar David Lindsay
Wos John August
Amber Gay Jack S. Jr.
Debiswanus
Dai Haiyan George
Sopar David Lindsay
Application Number:
JP2010145432A
Publication Date:
October 30, 2013
Filing Date:
June 25, 2010
Export Citation:
Assignee:
DUKE UNIVERSITY
International Classes:
A61K31/5575; A61K31/557; C07C405/00; A61P1/00; A61P9/12; A61P11/02; A61P13/10; A61P15/08; A61P17/00; A61P19/00; A61P19/08; A61P19/10; A61P27/02; A61P27/06; A61P43/00; C07C59/11; C07C59/72; C07C69/675; C07C69/736; C07C229/28; C07C239/14; C07C239/16; C07C259/06; C07C311/06; C07C317/06; C07C317/24; C07C317/46; C07C321/16
Domestic Patent References:
| JP58029710A | ||||
| JP52053841A | ||||
| JP51086449A | ||||
| JP49093342A | ||||
| JP4619531B2 | ||||
| JP7165703A | ||||
| JP6316525A | ||||
| JP1151552A |
Foreign References:
| WO1997023225A1 | ||||
| US5703108 |
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe