Title:
AROMATIC ANTIFUNGAL AGENT
Document Type and Number:
Japanese Patent JP3805905
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new aromatic antifungal agent having antifungal activity and useful as an antifungal agent.
SOLUTION: An aromatic compound of formula I (R1 is a group expressed by one of formulae II to IV; R2 is a hydrocarbon group having at least 6 π- electrons; R3 is a 1-4C alkyl) and/or a biologically permissible salt of the compound, for example, trans-N-(6,6-dimethyl-2-hepten-4-ynyl)-N- methyl-3-(phenylsulfonyl)benzylamine of formula V. The compound of formula I can be obtained by condensing a corresponding aromatic amine with a halide of a hydrocarbon group having 6 or more π-electrons in the presence of an alkali. For example, the compound of formula V is obtained by reacting 3- bromomethylphenylphenylsulfone with N-(6,6-dimethyl-2-hepten-4-ynyl) methylamine. Such a compound enables the expectation of excellent properties regarding safety and antifungal activity, for example, excellent antifungal activity against pathogenic fungus of trichophytia of foot and/or nail or the like.
Inventors:
Toshiro Mashima
Toshimitsu Suzuki
Masayuki Yuasa
Yukio Kawazu
Takao Ito
Takuji Nakajima
Akatsuki Nozawa
Toshimitsu Suzuki
Masayuki Yuasa
Yukio Kawazu
Takao Ito
Takuji Nakajima
Akatsuki Nozawa
Application Number:
JP24655498A
Publication Date:
August 09, 2006
Filing Date:
August 17, 1998
Export Citation:
Assignee:
POLA Kasei Kogyo Co., Ltd.
International Classes:
A61K31/135; C07C323/32; A61P17/00; A61P31/10; C07C317/32; (IPC1-7): C07C323/32; A61K31/135; C07C317/32
Domestic Patent References:
| JP64006245A | ||||
| JP63115851A | ||||
| JP1081649A |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
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