ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール－ビピリジンアミン誘導体

Japanese Patent JP7446236

B2

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula:wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.

Keschicki, Edward A.
Ravi, Canaan Kalkulichi
Lindstrom, Johann
Persson, Lars Boukarta
Libender, Madeleine
Vicland, Jenny
Ginman, Tobias
False Brom, Ricardo
Ram, Fredrick
Hickey, Eugene Earl.
Dahlgren, Markus K.
Gerachute, Alexei Ai.

JP2020554062A

March 08, 2024

December 21, 2018

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Ravenna Pharmaceuticals, Inc.

C07D213/56; A61K31/4433; A61K31/444; A61K31/4545; A61K31/455; A61K31/4709; A61K31/496; A61K31/4985; A61K31/501; A61K31/506; A61K31/519; A61K31/5377; A61K31/541; A61P1/04; A61P1/16; A61P1/18; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/08; A61P21/00; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D213/73; C07D213/82; C07D213/84; C07D401/14; C07D405/04; C07D417/14; C07D471/04; C07D471/10; C07D471/14; C07D487/04; C07D491/048; C07D491/056; C07D495/04; C07D498/04; C07D513/04; C07D519/00; C07F5/02

JP2016518389A
JP2009543765A
JP2009541268A
JP2018500376A
JP2011509277A
JP2009503103A

CN107417605A
WO2009087224A1
WO2009087225A2

Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito

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