Title:
ARYL COMPOUND AND BIARYL COMPOUND HAVING MCH MODULATORY ACTIVITY
Document Type and Number:
Japanese Patent JP2010001316
Kind Code:
A
Abstract:
To provide MCH receptor antagonists.
In one embodiment, a new class of compounds as MCH receptor antagonists, a method for producing such compounds, a pharmaceutical composition containing 1 kinds of such compounds, a method for preparing a pharmaceutical formulations containing 1 kinds of such compounds, and a method for treating, preventing or ameliorating 1 kinds of diseases associated with the MCH receptor are provided. An illustrative inventive compound is represented. In one embodiment, compounds having a general structure represented by formula I are disclosed. The compounds include enantiomers, stereoisomers, rotational isomers, tautomers and prodrugs and, in addition, pharmaceutically acceptable salts and solvates of the compounds and the prodrugs.
Inventors:
HOBBS DOUGLAS W
GUO TAO
HUNTER RACHAEL C
GU HUIZHONG
Application Number:
JP2009232046A
Publication Date:
January 07, 2010
Filing Date:
October 05, 2009
Assignee:
PHARMACOPEIA DRUG DISCOVERY
International Classes:
C07C233/78; A61K31/12; C07D295/12; A61K31/137; A61K31/165; A61K31/166; A61K31/17; A61K31/18; A61K31/192; A61K31/277; A61K31/341; A61K31/36; A61K31/381; A61K31/40; A61K31/4025; A61K31/4045; A61K31/4166; A61K31/417; A61K31/42; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4468; A61K31/4535; A61K31/454; A61K31/4545; A61K31/495; A61K31/5375; A61K45/00; A61P3/04; A61P3/10; A61P25/18; A61P43/00; C07C237/06; C07C237/20; C07C255/58; C07C255/60; C07C271/52; C07C271/54; C07C275/28; C07C275/30; C07C275/32; C07C275/34; C07C311/06; C07C311/07; C07C311/08; C07C311/13; C07C311/18; C07C311/19; C07C317/32; C07D207/08; C07D207/09; C07D207/12; C07D207/14; C07D209/14; C07D209/16; C07D211/58; C07D213/38; C07D213/40; C07D213/63; C07D213/75; C07D213/89; C07D233/36; C07D233/61; C07D233/64; C07D261/18; C07D295/13; C07D295/155; C07D295/205; C07D307/14; C07D317/58; C07D333/20; C07D333/38; C07D409/12; C07D413/12; C07D471/04; C07D211/22; C07D261/14; C07D295/20
Domestic Patent References:
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
