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Title:
アリールおよびヘテロアリール化合物ならびに凝固を調節する方法
Document Type and Number:
Japanese Patent JP2005535710
Kind Code:
A
Abstract:
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.

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Inventors:
Mujari, Adnan Em. Em.
Andrews, Rob
Guo, Xiao-Chuan
Kristen, Daniel Peter
Gohimukla, Devi Lady
Juan, Guoshan
Rothline, robert
Chagi, Samia
Yarmouth, Tripura
Boehme, Christopher
Application Number:
JP2004527986A
Publication Date:
November 24, 2005
Filing Date:
August 08, 2003
Export Citation:
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Assignee:
TRANSTECH PHARMA,INC.
International Classes:
A61K31/166; A61K31/167; A61K31/198; A61K31/341; A61K31/343; A61K31/381; A61K31/402; A61K31/4025; A61K31/4155; A61K31/4164; A61K31/421; A61K31/422; A61K31/4245; A61K31/433; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4453; A61K31/4465; A61K31/472; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61K31/55; A61K31/609; A61K31/625; A61K31/63; A61P7/02; A61P9/06; A61P9/10; A61P9/14; A61P13/12; A61P15/06; A61P29/00; A61P37/00; A61P41/00; A61P43/00; C07C233/29; C07C233/87; C07C235/42; C07C235/52; C07C235/60; C07C235/66; C07C237/20; C07C237/36; C07C237/42; C07C237/44; C07C255/58; C07C255/60; C07C257/18; C07C271/20; C07C271/44; C07C311/18; C07C311/19; C07C311/29; C07C311/44; C07C317/14; C07C317/28; C07C317/36; C07C317/46; C07C323/36; C07D207/09; C07D207/267; C07D207/27; C07D207/48; C07D211/14; C07D211/26; C07D213/30; C07D213/38; C07D213/55; C07D213/56; C07D213/70; C07D213/71; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D215/36; C07D217/02; C07D217/04; C07D217/16; C07D217/22; C07D217/26; C07D231/12; C07D231/14; C07D231/18; C07D233/84; C07D239/94; C07D249/08; C07D261/10; C07D263/32; C07D271/10; C07D277/20; C07D277/44; C07D277/46; C07D277/54; C07D285/06; C07D285/08; C07D295/08; C07D295/092; C07D295/14; C07D295/155; C07D307/52; C07D307/66; C07D307/79; C07D307/85; C07D317/60; C07D317/66; C07D333/20; C07D333/24; C07D333/38; C07D333/70; C07D401/04; C07D403/04; C07D409/04; C07D409/06; C07D413/04; C07D207/26; (IPC1-7): C07C233/29; A61K31/166; A61K31/167; A61K31/198; A61K31/223; A61K31/27; A61K31/277; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/40; A61K31/402; A61K31/4025; A61K31/415; A61K31/4155; A61K31/4164; A61K31/42; A61K31/421; A61K31/422; A61K31/4245; A61K31/426; A61K31/433; A61K31/44; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4453; A61K31/4465; A61K31/47; A61K31/472; A61K31/495; A61K31/501; A61K31/506; A61K31/517; A61K31/5375; A61K31/5377; A61K31/55; A61K31/609; A61K31/625; A61K31/63; A61P7/00; A61P7/02; A61P9/00; A61P9/06; A61P9/10; A61P9/14; A61P13/12; A61P15/06; A61P29/00; A61P37/00; A61P41/00; A61P43/00; C07C233/87; C07C235/38; C07C235/60; C07C235/66; C07C237/20; C07C237/36; C07C237/42; C07C255/58; C07C257/18; C07C271/20; C07C271/44; C07C311/08; C07C311/18; C07C311/21; C07C311/29; C07C311/44; C07C311/45; C07C317/14; C07C317/22; C07C317/46; C07C323/36; C07D207/09; C07D207/27; C07D207/48; C07D211/14; C07D211/26; C07D213/30; C07D213/38; C07D213/55; C07D213/56; C07D213/64; C07D213/71; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D215/36; C07D217/04; C07D217/16; C07D217/22; C07D217/26; C07D231/12; C07D231/14; C07D231/18; C07D233/84; C07D239/94; C07D249/08; C07D261/10; C07D263/32; C07D271/10; C07D277/20; C07D277/44; C07D277/54; C07D285/06; C07D295/08; C07D295/14; C07D307/52; C07D307/79; C07D307/85; C07D317/60; C07D317/66; C07D333/20; C07D333/24; C07D333/38; C07D333/70; C07D401/04; C07D403/04; C07D409/04; C07D409/06; C07D413/04
Domestic Patent References:
JP2002509131A2002-03-26
JPS5195047A1976-08-20
JP2001525400A2001-12-11
JP2004522759A2004-07-29
Foreign References:
WO2002018320A22002-03-07
GB2354440A2001-03-28
WO1999026923A11999-06-03
WO2001021584A12001-03-29
WO1995012611A11995-05-11
WO1997032863A11997-09-12
WO1999026922A11999-06-03
Attorney, Agent or Firm:
Hidekazu Miyoshi
Masakazu Ito



 
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