Title:
ARYLOXYPROPANOLAMINE BETA 3 ADRENERGIC RECEPTOR AGONIST
Document Type and Number:
Japanese Patent JPH08239349
Kind Code:
A
Abstract:
To obtain the compound having an activity against β3-adrenarine receptors and useful for treating diabetes, obesity, intestinal hyperkinesis, achalasia, etc.
A compound of formula I [R1-R3 are each H, hydroxy, an alkoxy, nitro or the like; R4-R9 are each H, an alkoxycarbonyl, hydroxy, a halogen, an alkyl or the like; (m) is 0 or 1] or its salt, for example, (S)-1-{[bis(4- methoxyphenyl)methyl]amino}-3-phenoxy-2-propanol. The compound of formula I is obtained by thermally coupling a compound of formula II with a compound of formula III in a solvent such as ethanol. The compound of formula I may be processed into a preparation together with a β1 or β2-adrenarine receptor blocker or an activator, and is preferably orally administered at a daily dose of 0.1-100 mg/kg.
Inventors:
FUIRITSUPU EMU SHIEERU
UIRIAMU ENU UOTSUSHIYUBAAN
KIYASURIIN EMU POSU
Application Number:
JP31405695A
Publication Date:
September 17, 1996
Filing Date:
December 01, 1995
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
A61K31/135; A61K31/165; A61K31/18; A61K31/215; A61K31/275; A61K31/357; A61K31/36; A61K31/41; A61K31/415; A61K31/4184; A61K31/42; A61K31/423; A61K31/47; A61P1/00; A61P3/04; A61P3/08; A61P3/10; A61P25/02; A61P43/00; C07C217/30; C07C217/58; C07C217/84; C07C237/30; C07C311/08; C07C317/32; C07C317/36; C07D209/42; C07D215/22; C07D215/227; C07D215/26; C07D235/26; C07D249/18; C07D263/58; C07D317/58; C07D405/12; (IPC1-7): C07C217/58; A61K31/135; A61K31/165; A61K31/18; A61K31/215; A61K31/275; A61K31/36; A61K31/41; A61K31/415; A61K31/42; A61K31/47; C07C217/84; C07C311/08; C07C317/36; C07D209/42; C07D215/22; C07D235/26; C07D249/18; C07D263/58; C07D317/58; C07D405/12
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
