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Title:
ARYLTHIOALKYLPHENYL CARBOXYLIC ACIDS
Document Type and Number:
Japanese Patent JPS6426548
Kind Code:
A
Abstract:

NEW MATERIAL: The compd. of formula I [Ar is aryl; A is formula II (R2 and R3 are each H or lower alkyl), etc.; R is H, alkaline metal or lower alkyl; n is 0 to 2; m is 0 to 3; p is 1 to 5; q is 0 to 3; r is 0 to 3; (CH2)m, (CH2)p and (CH2)r are each nonsubstd. or a group substd. with lower alkyl or lower alkoxy].

EXAMPLE: 4-(3-((4-chlorophenyl)sulfonyl)proplyl)benzene acetic acid.

USE: An arachidonic acid inductive platelet coagulation inhibitor and bronchiostenosis inhibitor. Useful for the treatment of a thrombosis, angina pectoris, asthma. etc.

PROCESS: The compd. of the formula I is obtd. by alkylating the mercaptan of formula III to introduce the same to a sulfide compd., then treating the compd. with a base and subjecting the compd. to base hydrolysis and further to neutralization with an acid.


Inventors:
SUTEIIBUN II HOORU
FUIRITSUPU DEII SUTEIN
Application Number:
JP16237188A
Publication Date:
January 27, 1989
Filing Date:
June 28, 1988
Export Citation:
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Assignee:
SQUIBB & SONS INC
International Classes:
A61K31/215; A61P7/02; A61P11/00; C07C67/00; C07C313/00; A61K31/19; C07C317/00; C07C317/04; C07C317/44; C07C323/22; C07C323/56; C07C323/62; (IPC1-7): A61K31/19; A61K31/215; C07C147/107; C07C147/14; C07C149/273
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)