Title:
ASCORBIC ACID BULK PARTICLE FOR DIRECT TABLETING BY SPHERICAL CRYSTALLIZATION TECHNIQUE, ITS PRODUCTION AND TABLET USING THE SAME
Document Type and Number:
Japanese Patent JP3172695
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain ascorbic acid particles remarkably improved in flowability and packability and suitable for a direct tabletting method not using an additive by applying a spherical crystallization method to ascorbic acid powder.
SOLUTION: The particles are obtained by dissolving ascorbic acid powder in a good solvent (especially preferably water) and subsequently dropping the solution in a poor solvent at a lower temperature than that of the good solvent with stirring. The poor solvent is preferably a solvent having a solubility parameter (Mpa1/2) comprising a δ d of 15-17, a δ p of 3-6 and a δ h of 6-12, especially ethyl acetate, isopropyl acetate, etc. In the method, it is preferable to drop the solution in a 27-100 fold-volume of the poor solvent.
Inventors:
Yoshiaki Kawashima
Hirofumi Takeuchi
Chisho Hino
Hiromitsu Yamamoto
Kazunori Kamiya
Kodama Seiichi
Todoroki Hiroshi
Hirofumi Takeuchi
Chisho Hino
Hiromitsu Yamamoto
Kazunori Kamiya
Kodama Seiichi
Todoroki Hiroshi
Application Number:
JP22722897A
Publication Date:
June 04, 2001
Filing Date:
August 07, 1997
Export Citation:
Assignee:
BASF Akchen Gezel Shaft
International Classes:
A61K9/16; A61K31/375; (IPC1-7): A61K31/375; A61K9/16
Domestic Patent References:
| JP477422A | ||||
| JP53101518A |
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)
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