Title:
ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH
Document Type and Number:
Japanese Patent JP2022137128
Kind Code:
A
Abstract:
To provide small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.SOLUTION: There is provided a compound of formula, wherein X is S, O, NH or CH2; and wherein L is composed of 0-3 C, S, O, and/or N, and when the component L is 0 members there is no bond at the position of L.SELECTED DRAWING: Figure 1
Inventors:
Glenbecca, Joranta
Ciel Piki, Thomas
Logausky, David
Bourkin, Dmitry
Kurosowski, Simon
Chuan, Jin
Montgomery, Diana
Den, gin
Shevtic, Malta
Li, Hao
Ciel Piki, Thomas
Logausky, David
Bourkin, Dmitry
Kurosowski, Simon
Chuan, Jin
Montgomery, Diana
Den, gin
Shevtic, Malta
Li, Hao
Application Number:
JP2022106297A
Publication Date:
September 21, 2022
Filing Date:
June 30, 2022
Export Citation:
Assignee:
The Regents of the University of Michigan
International Classes:
C07C327/48; A61K31/16; A61K31/18; A61K31/381; A61K31/402; A61K31/415; A61K31/4178; A61K31/423; A61K31/426; A61K31/428; A61K31/433; A61K31/4418; A61K31/4439; A61K31/454; A61K31/496; A61K31/5377; A61K31/55; A61K31/69; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07C323/45; C07D207/327; C07D209/08; C07D209/14; C07D209/18; C07D209/42; C07D209/46; C07D213/83; C07D223/22; C07D231/38; C07D277/56; C07D277/82; C07D333/18; C07D333/38; C07D401/04; C07D401/14; C07D403/06; C07D403/12; C07D405/04; C07D407/12; C07D407/14; C07D417/14; C07D471/04; C07D471/08; C07D487/04; C07D493/10
Attorney, Agent or Firm:
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK
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