Title:
糖尿病の迅速スクリーニングのアッセイ方法およびキット
Document Type and Number:
Japanese Patent JP2006506631
Kind Code:
A
Abstract:
The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
Inventors:
Morris, Carol Ann
Carney, Fiona Patricia
Lane, Jennifer Down
Carney, Fiona Patricia
Lane, Jennifer Down
Application Number:
JP2004552665A
Publication Date:
February 23, 2006
Filing Date:
November 19, 2003
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
G01N33/50; A61B5/00; C12Q1/54; G01N33/48; G01N33/53; G01N33/542; G01N33/66; G01N33/68
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Koshiro Tsukuda
Fumio Shinoda
Koshiro Tsukuda