Title:
不斉尿素化合物およびこれを触媒として用いる不斉共役付加反応による不斉化合物の製造方法
Document Type and Number:
Japanese Patent JP4384635
Kind Code:
B2
Abstract:
The present invention relates to a production method of asymmetric compound (IV) which includes conjugately adding nucleophilic reagent (III) to compound (II) in the presence of asymmetric urea compound (I). The present invention provides a non-metallic asymmetric catalyst capable of realizing a highly stereoselective asymmetric conjugate addition reaction in a high yield, and an advantageous production method of an asymmetric compound by an asymmetric conjugate addition reaction using the asymmetric catalyst.
wherein X is an oxygen atom or a sulfur atom; C*, C** and C*** are asymmetric carbons; R 1 , R 2 , R 4 , R 5 , R 8 , R 9 and R 10 are each a lower alkyl group optionally having substituent(s) and the like, or R 4 and R 5 and the like in combination optionally form a homocyclic ring optionally having substituent(s) and the like; R 3 is an aryl group optionally having substituent(s) and the like; R 6 and R 7 are each a hydrogen atom and the like; Nu is -CR 16 (COR 17 ) (COR 18 ) wherein R 16 , R 17 and R 18 are each a lower alkyl group optionally having substituent(s) and the like, and the like; and EWG is an electron withdrawing group.
Inventors:
Takemoto Koji
Application Number:
JP2005511107A
Publication Date:
December 16, 2009
Filing Date:
June 25, 2004
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
Takemoto Koji
Takemoto Koji
International Classes:
C07C335/20; C07C201/12; C07C205/40; C07C205/41; C07C205/51; C07C205/53; C07C205/55; C07C231/10; C07C231/12; C07C231/18; C07C233/47; C07C235/78; C07C269/06; C07C275/30; C07C275/40; C07C335/16; C07C335/18; C07D209/08; C07D209/56; C07D333/24; C07B53/00; C07B61/00; C07C271/22; C07D
Domestic Patent References:
| JP2007502311A | ||||
| JP2005533038A | ||||
| JP2005516947A | ||||
| JP2001031682A | ||||
| JP6256228A | ||||
| JP57197264A |
Foreign References:
| WO2003045937A1 |
Other References:
Tetrahedron: Asymmetry,2001年,12(2),p.329-336
Journal of Organic Chemistry,2000年,65(23),p.7774-7778
Heterocycles,1990年,31(10),p.1837-1846
Journal of Organic Chemistry,2000年,65(23),p.7774-7778
Heterocycles,1990年,31(10),p.1837-1846
Attorney, Agent or Firm:
Takashima Ichi