Title:
遺伝子ワクチンのための弱毒化vifDNA免疫化カセット
Document Type and Number:
Japanese Patent JP4418101
Kind Code:
B2
Abstract:
The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor ( vif ) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in order to induce a cellular and humoral immune response to the encoded protein product.
Inventors:
Aiyavu, Verpandi
Naga Sungum Gum, Sanada Valayan
Weiner, David Bee
Naga Sungum Gum, Sanada Valayan
Weiner, David Bee
Application Number:
JP2000511515A
Publication Date:
February 17, 2010
Filing Date:
September 18, 1998
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N15/09; A61K38/00; A61K39/12; A61K39/21; A61K39/38; A61K39/395; A61K39/40; A61K39/42; A61P31/18; A61P37/02; C07K1/00; C07K14/155; C07K14/16; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/04; C12P21/06; A61K39/00
Other References:
J. Virol.,1994年,Vol.68, No.3,p.1714-1720
J. Biol. Chem.,1996年,Vol.271, No.17,p.10121-10129
DNA Cell Biol.,1996年,Vol.15, No.5,p.353-361
J. Virol.,1995年,Vol.69, No.4,p.2557-2564
J. Biol. Chem.,1996年,Vol.271, No.17,p.10121-10129
DNA Cell Biol.,1996年,Vol.15, No.5,p.353-361
J. Virol.,1995年,Vol.69, No.4,p.2557-2564
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita