Title:
Aza-heterocycle by which it was replaced for the disposal of cancer
Document Type and Number:
Japanese Patent JP6116554
Kind Code:
B2
Abstract:
The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
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Inventors:
Heinrich, Timo
Bulgur, nadia
Josephson, Christopher
Bulgur, nadia
Josephson, Christopher
Application Number:
JP2014517492A
Publication Date:
April 19, 2017
Filing Date:
June 11, 2012
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D401/04; A61K31/506; A61K31/52; A61K31/5377; A61P1/18; A61P3/10; A61P9/10; A61P13/08; A61P13/12; A61P17/00; A61P17/06; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P29/02; A61P35/00; A61P43/00; C07D401/14; C07D405/14; C07D413/14; C07D417/14; C07D471/04; C07D473/34
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Foreign References:
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Other References:
WU YANG,DISCOVERY AND STRUCTURE- ACTIVITY RELATIONSHIPS OF TRISUBSTITUTED PYRIMIDINES/PYRIDINES 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2009年 2月26日,V52 N4,P1204-1208,AS NOVEL CALCIUM-SENSING RECEPTOR ANTAGONISTS
EL-DEEB, IBRAHIM MUSTAFA,DESIGN AND SYNTHESIS OF NEW ANTICANCER PYRIMIDINES WITH MULTIPLE-KINASE INHIBITORY EFFECT,BIOORGANIC & MEDICINAL CHEMISTRY,2010年,V18 N11,P3860-3874
MARIE M. AHLSTROEM,CHARACTERIZATION OF TYPE II LIGANDS IN CYP2C9 AND CYP3A4,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2008年 3月 1日,V51 N6,P1755-1763
REGISTRY(STN)[online]、2007.12.26[検索日 2015.12.10],CAS登録番号 959556-04-8
NANCY ZHOU,DISCOVERY OF N-(2-AMINOPHENYL)-4-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YLAMINO) 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2008年 7月 1日,V51 N14,P4072-4075,METHYL]BENZAMIDE(MGCD0103), AN ORALLY ACTIVE HISTONE DEACETYLASE INHIBITOR
Jae Chun Ryu, et al.,Synthesis of new N-arylpyrimidin-2-amine derivatives using a palladium catalyst,Molecules,2008年,13(4),818-830
EL-DEEB, IBRAHIM MUSTAFA,DESIGN AND SYNTHESIS OF NEW ANTICANCER PYRIMIDINES WITH MULTIPLE-KINASE INHIBITORY EFFECT,BIOORGANIC & MEDICINAL CHEMISTRY,2010年,V18 N11,P3860-3874
MARIE M. AHLSTROEM,CHARACTERIZATION OF TYPE II LIGANDS IN CYP2C9 AND CYP3A4,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2008年 3月 1日,V51 N6,P1755-1763
REGISTRY(STN)[online]、2007.12.26[検索日 2015.12.10],CAS登録番号 959556-04-8
NANCY ZHOU,DISCOVERY OF N-(2-AMINOPHENYL)-4-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YLAMINO) 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2008年 7月 1日,V51 N14,P4072-4075,METHYL]BENZAMIDE(MGCD0103), AN ORALLY ACTIVE HISTONE DEACETYLASE INHIBITOR
Jae Chun Ryu, et al.,Synthesis of new N-arylpyrimidin-2-amine derivatives using a palladium catalyst,Molecules,2008年,13(4),818-830
Attorney, Agent or Firm:
Kiyoji Kuzuwa
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