Title:
Ｍａｔ２Ａのアザ複素二環式阻害剤、およびがんの治療のための使用方法
Document Type and Number:
Japanese Patent JP7418441
Kind Code:
B2
Abstract:
The present disclosure provides for compounds according to Formula I and their pharmaceutically acceptable salts, tautomers, and/or isotopologues as described in the disclosure. The compounds are inhibitors of methionine adenosyltransferase isoform 2A (MAT2A). Also provided are pharmaceutical compositions and methods of using the compounds for treating cancers, including some cancers in which the gene encoding methylthioadenosine phosphorylase (MTAP) is deleted.
Inventors:
Conteatis, Zenon Dee.
Li, Minzon
Resnick, Samuel K.
Sui, Ziffa
Li, Minzon
Resnick, Samuel K.
Sui, Ziffa
Application Number:
JP2021538127A
Publication Date:
January 19, 2024
Filing Date:
December 27, 2019
Export Citation:
Assignee:
Les Laboratoires Servier
International Classes:
C07D471/04; A61K31/5025; A61K31/506; A61K31/538; A61K31/695; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P11/00; A61P11/02; A61P11/04; A61P13/02; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/08; A61P21/00; A61P25/00; A61P25/02; A61P27/02; A61P27/16; A61P35/00; A61P35/02; A61P43/00; C07D519/00; C07F7/12
Domestic Patent References:
| JP2021519783A | ||||
| JP2004509113A |
Foreign References:
| WO2018045071A1 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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