Title:
新規な経口活性を有するアゾール誘導体
Document Type and Number:
Japanese Patent JP4652223
Kind Code:
B2
Abstract:
The present invention relates to new orally active azole derivatives with antifungal activity of formula I wherein: X is CH or N; Ar represents phenyl substituted with halogen and/or trifluoromethyl; Z is -C(=O)- or -SO2-; R1 is CN, CO2H, CO2R7, CONR8R9 or CH2Y and then R3 is hydrogen, or R1 together with R3 forms a ring of formula I' wherein B is O, hydroxy or hydrogen; R4 is C1-4 alkyl; R5, R6, R8 and R9 are hydrogen or C1-4 alkyl; Y is -OH, -OR7, -OC(=O)R7, -NR8R9,-NHC(=O)OR7; R7 is C1-C4-alkyl, phenyl-C1-C4-alkyl or optionally substituted phenyl; when Z is -C(=O)-, R2 is optionally susbtituted phenyl, naphtyl, or an heterocycle; when Z is -SO2-, R2 is C1-4 alkyl, phenyl-C1-4-alkyl or optionally susbtituted phenyl.
Inventors:
Javier, Bartoroli
Enrique, Toulmo
Manuel, Anguita
Elena, Carselel
Carmen, Almansa
Enrique, Toulmo
Manuel, Anguita
Elena, Carselel
Carmen, Almansa
Application Number:
JP2005364733A
Publication Date:
March 16, 2011
Filing Date:
December 19, 2005
Export Citation:
Assignee:
Palau Pharma, S.A.
International Classes:
A01N43/50; A01N43/653; C07D249/08; A01N43/76; A01N43/84; A01N47/12; A61K31/41; A61K31/415; A61P31/04; A61P31/10; C07D233/54; C07D233/60; C07D233/61; C07D263/22; C07D303/38; C07D407/12; C07D413/06; C07D413/14; C07D521/00; A61K31/4196
Domestic Patent References:
| JP59082376A |
Foreign References:
| WO1992017474A1 |
Other References:
Chem. Pharm. Bull,1992年,Vol.40, No.3,p.661-665
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota