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Title:
AZULENE-CONTAINING LIQUID FORMULATION
Document Type and Number:
Japanese Patent JPS6351341
Kind Code:
A
Abstract:

PURPOSE: To obtain an azulene-containing liquid formulation, by blending a liquid formulation containing azulene compound with a hydrogencarbonate and using an alcohol in a specific concentration as a solvent to stabilize the azulele compound and capable of exhibiting improved stability even by preservation under severe condition for a long period.

CONSTITUTION: An azulene-containing liquid formulation, obtained by blending 0.0001W5.0wt.% hydrogen carbonate with a liquid formulation containing an azulene compound, e.g. guaiazulene or sodium guaiazulenesulfonate, etc., in an amount of 0.001W1.0wt.% based on the total weight of the composition and using an alcohol is 30W100wt.% concentration as a solvent and preferably further blending a quaternary ammonium salt, particularly cetylpyridinium chloride, benzethonium chloride or/and benzalkonium chloride in an amount of 0.001W5.0wt.% based on the total weight to improve light and heat resistance of the azulene compound and having ≥90% residual ratio of the azulene com pound even after preserving, e.g. at 40°C for ≥6 months.


Inventors:
YOSHIKAWA MASARU
KAMEDA SEIJI
KON AKIRA
KASUDA MIDORI
Application Number:
JP19453786A
Publication Date:
March 04, 1988
Filing Date:
August 20, 1986
Export Citation:
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Assignee:
LION CORP
International Classes:
A61K31/185; A61K9/10; A61K31/015; A61P17/00; A61P29/00; A61P37/08; C07C1/00; C07C7/20; C07C13/52; C07C67/00; C07C301/00; C07C303/42; C07C309/25; (IPC1-7): A61K9/10; A61K31/015; A61K31/185; C07C7/20; C07C13/52; C07C139/14; C07C143/22
Attorney, Agent or Firm:
Toshiaki Ikeura