Title:
ＢＲＡＦ阻害剤に対する耐性を付与するＢＲＡＦ突然変異
Document Type and Number:
Japanese Patent JP5933459
Kind Code:
B2
Abstract:
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.
More Like This:
Inventors:
Gallaway, Levy
Emery, caroline
Emery, caroline
Application Number:
JP2012555071A
Publication Date:
June 08, 2016
Filing Date:
February 22, 2011
Export Citation:
Assignee:
Dana Faber Cancer Institute, Incorporated
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12P21/02; C12Q1/48; G01N33/15; G01N33/50; G01N33/53; G01N33/574
Foreign References:
| WO2010007030A1 | ||||
| WO2008125820A1 | ||||
| WO2008079903A1 |
Other References:
HEIDORN SONJA J. et al,KINASE-DEAD BRAF AND ONCOGENIC RAS COOPERATE TO DRIVE TUMOR PROGRESSION THROUGH CRAF,CELL,2010年 1月22日,Vol. 140, No. 2,p. 209-221
WHITTAKER STEVEN et al,GATEKEEPER MUTATIONS MEDIATE RESISTANCE TO BRAF-TARGETED THERAPIES,SCIENCE TRANSLATIONAL MEDICINE,2010年 6月 9日,Vol. 2, No. 35, 35RA41,p. 1-10
ROSKOSKI ROBERT JR.,RAF PROTEIN-SERINE/THREONINE KINASES: STRUCTURE AND REGULATION,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010年 7月30日,Vol. 399, No. 3,p. 313-317
Emery et al,PNAS,2009年12月 1日,Vol. 106, No. 48,p. 20411-20416
Emery et al,PNAS,2009年12月 1日,Vol. 106, No. 48,p. 20411-204116
WHITTAKER STEVEN et al,GATEKEEPER MUTATIONS MEDIATE RESISTANCE TO BRAF-TARGETED THERAPIES,SCIENCE TRANSLATIONAL MEDICINE,2010年 6月 9日,Vol. 2, No. 35, 35RA41,p. 1-10
ROSKOSKI ROBERT JR.,RAF PROTEIN-SERINE/THREONINE KINASES: STRUCTURE AND REGULATION,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010年 7月30日,Vol. 399, No. 3,p. 313-317
Emery et al,PNAS,2009年12月 1日,Vol. 106, No. 48,p. 20411-20416
Emery et al,PNAS,2009年12月 1日,Vol. 106, No. 48,p. 20411-204116
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama