Title:
BASE FOR SUSTAINED RELEASE PHARMACEUTICAL PREPARATION ATTACHED TO ORAL MUCOSA AND SUSTAINED RELEAES PHARMACEUTICAL PREPARATION ATTACHED TO ORAL MUCOSA
Document Type and Number:
Japanese Patent JP3475567
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject base comprising an amorphous agar and a cellulose derivative and capable of imparting excellent handleability, controlling property of medicine release, binding (durable) property and swelling resistance due to saliva, etc.
CONSTITUTION: This base contains (A) an amorphous agar (e.g. readily water-soluble powdery agar in which dissolution ratio when retained for 10min in water kept to 70°C at a concentration of 1.5% is ≥50%, and especially, dissolution ratio when retained at 80°C for 10min in water kept to 80°C at a concentration of 1.5% is 100% and having dissolution limit due to boiling exceeding 3% under ordinary pressure or powdery agar obtained by grinding crystalline agar until becoming amorphous by a grinder) and (B) a cellulose derivative (e.g. hydroxypropyl(methyl)cellulose or carboxymethyl-cellulose sodium salt).
Inventors:
Kazuhiko Tsukada
Haruhiko Takahashi
Maeda Hidee
Takayoshi Kimura
Haruhiko Takahashi
Maeda Hidee
Takayoshi Kimura
Application Number:
JP9082695A
Publication Date:
December 08, 2003
Filing Date:
April 17, 1995
Export Citation:
Assignee:
Tsumura Co., Ltd.
International Classes:
A61K9/20; A61K9/70; A61K47/36; A61K47/38; C08B11/193; C08B37/12; (IPC1-7): A61K47/36; A61K9/20; A61K9/70; A61K47/38; C08B11/193; C08B37/12
Domestic Patent References:
| JP5509104A |
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)
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