BASIC L-AMINO ACID L-MALIC ACID SALT CRYSTAL AND ITS PREPARATION

Japanese Patent JPS55136254

A

NEW MATERIAL:Basic L-amino acid.L-malic acid salt crystal.

EXAMPLE: Neutral L-ornithine.L-malate dihydrate crystal.

USE: Medicine and nutrition enriching additive. Especially useful as an improved amino acid transfusion composition. The defects of a free basic L-amino acid or a besic L-amino acid hydrochloside, such as moisture absorption, bitter taste, acidosis caused by transfusion, etc. are improved by converting the basic L-amino acid into its L-malate.

PROCESS: L-Malic acid is dissolved in an aqueous solvent containing a free basic L-amino acid (e.g. L-lysine, L-ornithine, L-arginine, etc.) to adjust the pH of the solution within 6.5W7.5, and a hydrophilic organic solvent (e.g. methanol, acetone, etc.) is added to thereto, to separate out the desired crystal. The crystallization can be accelerated by adding a seed crystal. The molor ratio of the basic L-amino acid to L-malic acid is pref. 2 to 1.

WO/2017/114456	SALT OF MORPHOLINE DERIVATIVE AND CRYSTALLINE FORM THEREOF, AS WELL AS PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE OF THE SAME
JP4499664	Non-heat treatment method for concentrating Garcinia extract
JPS5569546	NEUTRAL L-LYSINE L-MALIC ACID SALT MONOHYDRATE CRYSTAL AND ITS PREPARATION

SENHATA ICHIROU
WASHIMI AKIHIKO
ITOU HIROSHI
OOTSUKI OSAMU
IZUTSU NOZOMI

JP4237879A

October 23, 1980

April 06, 1979

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TANABE SEIYAKU CO

C07C59/245; C07C51/00; C07C67/00; C07C227/18; C07C229/26; C07C239/00; C07C279/14; (IPC1-7): C07C59/245; C07C99/00; C07C101/24; C07C128/00; C07C129/12

JPS53143603A	1978-12-14
JPS5277011A	1977-06-29
JPS484012A

DE2153691A1

1973-03-29

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