PIG MODEL OF BECKER MUSCULAR DYSTROPHY CARDIOMYOPATHY

Title:

PIG MODEL OF BECKER MUSCULAR DYSTROPHY CARDIOMYOPATHY

Document Type and Number:

Japanese Patent JP2022153749

Kind Code:

A

Abstract:

To establish a model large animal of Becker muscular dystrophy (BMD) cardiomyopathy, especially a model pig (male pig) often used for evaluation of a blood circulation system and/or a carrier pig (female pig) keeping the model pig as a strain, and to provide a method for sorting mother pigs giving birth to BMD model pigs.SOLUTION: A method for sorting mother pigs giving birth to BMD model pigs includes: administering an anesthetic to male piglets born from the mother pigs; and using decline in the cardiac function induced by the administration as an index. The sorting method of the mother pigs is established and on the basis of the sorting method, a male pig as the BMD cardiomyopathy model pig and a carrier female pig of the cardiomyopathy are constructed, both pigs characterized by having mutated dystrophin genes obtained by artificially inducing deletion of exon 21-28 regions.SELECTED DRAWING: None

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Inventors:

AIHARA NAOYUKI
KAMIIE JUNICHI
NOGUCHI RINKO
KANAI EIICHI

Application Number:

JP2021056429A

Publication Date:

October 13, 2022

Filing Date:

March 30, 2021

Export Citation:

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Assignee:

AZABU JUI GAKUEN

International Classes:

A01K67/027; C12Q1/02; C12Q1/686; C12Q1/6869

Attorney, Agent or Firm:

Koji Okuhara
Sumito Sekimoto

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