Title:
ベンズアミド誘導体
Document Type and Number:
Japanese Patent JP4844961
Kind Code:
B2
Abstract:
To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for producing the compounds, intermediate compounds useful for their production, and pharmaceutical compositions containing these compounds. The present invention provides compounds of formula (II), or prodrugs thereof, or pharmaceutically acceptable salts of the compounds or the prodrugs, and pharmaceuticals, and pharmaceutical compositions containing these compounds:
whereA 1 is C-X 1 or N; Q 1 is -A 2 =A 3 -, or a heteroatom selected from -O-, -S-, and -N(R 10 )-; Q 2 is -A 4 =A 5 -, or a heteroatom selected from -O-, -S-, and -N(R 10 )-; provided that Q 1 and Q 2 are not heteroatoms at the same time; A 2 is C-X 2 or N, A 3 is C-X 3 or N, A 4 is C-X 4 or N, and A 5 is C-X 5 or N; Y is C 1-6 alkyl, C 3-9 cycloalkyl, C 2-7 alkenyl, C 2-7 alkynyl, C 1-6 alkoxy, C 2-7 alkenyloxy, C 2-7 alkynyloxy, or C 1-6 alkylthio; Z is a hydrogen atom, hydroxy, C 1-6 alkyl, C 3-9 cycloalkyl, or -NR 1 R 2 ; and L is selected from the formula:
Inventors:
Hiroshi Oyano
Atsushi Suda
Aso Kosuke
Junto Haneda
Asai Sachi
Hasegawa Masami
Yasuko Sato
Atsushi Suda
Aso Kosuke
Junto Haneda
Asai Sachi
Hasegawa Masami
Yasuko Sato
Application Number:
JP2005516699A
Publication Date:
December 28, 2011
Filing Date:
December 27, 2004
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07C235/46; A61K31/166; A61K31/277; A61K31/40; A61K31/4196; A61K31/4409; A61P35/00; A61P35/04; A61P43/00; C07C233/65; C07C233/66; C07C235/48; C07C235/52; C07C235/54; C07C235/64; C07C237/22; C07C237/40; C07C243/38; C07C255/29; C07C255/57; C07C259/10; C07C309/65; C07C323/42; C07C323/62; C07D207/50; C07D209/08; C07D213/40; C07D213/56; C07D213/75; C07D215/38; C07D233/54; C07D249/08; C07D277/82; C07D295/155; C07D295/32; C07D307/14; C07D307/52; C07D333/36
Domestic Patent References:
| JPS474783U | 1972-09-12 | |||
| JP2003533450A | 2003-11-11 |
Foreign References:
| WO1997003967A1 | 1997-02-06 | |||
| WO2002064547A2 | 2002-08-22 | |||
| WO2002059080A2 | 2002-08-01 | |||
| WO2003103655A1 | 2003-12-18 | |||
| US6632961B1 | 2003-10-14 |
Attorney, Agent or Firm:
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi