Title:
第二級アミド基を有するベンズアゼピンジカルボキサミド化合物
Document Type and Number:
Japanese Patent JP7022702
Kind Code:
B2
Abstract:
This invention relates to new benzazepine dicarboxamide compounds of the formula (I) wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
Inventors:
One, Leisher
Yun, Hong In
Chan, WeChat
Chu, Way
Chan, Qi Wei
Yun, Hong In
Chan, WeChat
Chu, Way
Chan, Qi Wei
Application Number:
JP2018560995A
Publication Date:
February 18, 2022
Filing Date:
May 19, 2017
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D223/16; A61K31/55; A61P11/06; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D413/12; C07D417/12
Domestic Patent References:
| JP2009504763A | ||||
| JP2013502430A | ||||
| JP2013502431A | ||||
| JP2014505692A |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation