BENZENE DERIVATIVE

Japanese Patent JP2000159751

A

To obtain a new orally administrable compound having fibrinogenolysis promotive action, therefore useful as an antithrombotic agent or thrombolytic agent.

This new compound is a compound of formula I [X is OH, carboxyl or the like; Z is a heterocyclic group of formula II, formula III (R6 is H or methyl; R7 is H, carboxyl or the like; R8 is OH, a lower alkoxy or the like) or the like; Y is a single bond, CH=CH, NH or the like], e.g. (E)-2-[2-(4-hydroxyphenyl)ethenyl]-6-methylpyrimidin-4-ol. The compound of formula I (e.g. a compound where Z is a group of formula III) is obtained by reaction between a compound of formula IV (R11 is a lower alkoxycarbonyl or lower acyl; R12 is H or a lower alkoxyalkenyl; R13 is a lower alkyl) and a compound of formula V.

NAKATOGAWA KIYOSHI
MURATA MASANAO
TAKAGI MASAMICHI
IKEDA SHIGERU

JP33174898A

June 13, 2000

November 20, 1998

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TORII YAKUHIN KK

C07D251/24; A61K31/00; A61K31/41; A61K31/415; A61K31/4164; A61K31/4245; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4418; A61K31/4427; A61K31/496; A61K31/505; A61K31/506; A61K31/53; A61P7/00; A61P7/02; A61P43/00; C07D213/30; C07D231/20; C07D233/22; C07D233/50; C07D233/96; C07D239/24; C07D239/36; C07D271/06; C07D277/10; C07D401/12; C07D401/14; C07D403/12; (IPC1-7): C07D239/24; A61K31/415; A61K31/4164; A61K31/4245; A61K31/426; A61K31/4402; A61K31/505; A61K31/506; A61K31/53; A61P7/02; A61P43/00; C07D213/30; C07D231/20; C07D233/22; C07D233/50; C07D233/96; C07D239/36; C07D251/24; C07D271/06; C07D277/10; C07D401/12; C07D401/14; C07D403/12

Akira Asamura (3 outside)

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