Title:
ベンゼン縮合複素環誘導体およびその医薬組成物
Document Type and Number:
Japanese Patent JP7296948
Kind Code:
B2
Abstract:
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): is a single or double bond; n is an integer of 0 or 1; A is —CH2—, —CH(OH)—, or —C(O)—; G is C or N; X is —CH2—, O, or —C(O)—; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, —NRy1Ry2, —ORy1, —Ry1C(O)Ry3, —C(O)Ry1, —C(O)ORy2, —C(O)ORy2Ry3, —NRy1C(O)Ry2, —NRy1C(O)NRy2Ry3, —NRy1C(O)ORy2Ry3, —NRy1C(O)Ry2ORy3, C(O)NRy1(Ry2Ry3), —C(O)NRy1(Ry2ORy1), —ORy2Ry3, and —ORy2ORy3, wherein each of Ry1 and Ry2 is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and Ry3 is aryl optionally substituted with at least one halogen; Z is —NRz1Rz2, —NRz1Rz3, —ORz1, —ORz1Rz3, —C(O)Rz1Rz3, —C(O)ORz1Rz3, —NRz1C(O)Rz2Rz3, —NRz1C(O)ORz2Rz3, —C(O)NRz1Rz3, or ORz2ORz3, wherein each of Rz1 and Rz2 is independently selected from a group consisting of H, oxygen, alkyl and aryl, and Rz3 is aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, —RzaCOORzb, —ORzaCOORzb, —RzaSO2Rzb, —RzaSO2NRzbRzcRzd, —RzaC(O)RzbRzc, —RzaC(O)NRzbRzcRzd, —RZaC(O)NRzbSO2Rzc, wherein Rza is nil or alkyl, Rzb is H or alkyl, each of Rzb and Rzc is independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NRzbRzc is a nitrogen-containing heterocyclic alkyl ring, Rzd is nil or a sulfonyl alkyl group.
Inventors:
Yang Shauran S.
Li Kuan Yuan
Liu Meng Shen
Jiang Yan-Feng
Huang Yuxiou
Chen Chi-Han
Liu Sheng Hung
Li Kuan Yuan
Liu Meng Shen
Jiang Yan-Feng
Huang Yuxiou
Chen Chi-Han
Liu Sheng Hung
Application Number:
JP2020514196A
Publication Date:
June 23, 2023
Filing Date:
September 07, 2018
Export Citation:
Assignee:
Nusoara Biopharma Company Limited
International Classes:
C07C65/40; A61K31/122; A61K31/166; A61K31/167; A61K31/17; A61K31/18; A61K31/192; A61K31/235; A61K31/27; A61K31/343; A61K31/4035; A61K31/445; A61K31/472; A61K31/495; A61K31/60; A61P1/16; A61P11/00; A61P35/00; A61P43/00; C07C49/747; C07C49/755; C07C59/70; C07C59/72; C07C65/28; C07C69/773; C07C69/94; C07C233/33; C07C235/46; C07C235/84; C07C259/10; C07C271/28; C07C271/30; C07C275/38; C07C311/29; C07C311/51; C07C317/18; C07C317/22; C07D209/48; C07D211/22; C07D217/24; C07D295/20; C07D295/26; C07D307/83
Domestic Patent References:
| JP2004043482A | ||||
| JP51110573A | ||||
| JP10510537A | ||||
| JP2005526796A | ||||
| JP10273467A | ||||
| JP2290869A | ||||
| JP52014787A |
Foreign References:
| WO2011053511A1 | ||||
| CN106278857A | ||||
| CN106008324A | ||||
| US4569689 | ||||
| WO2016195361A1 |
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Bioorg. Med. Chem. Lett.,1998年,Vol. 8,2489-2494
薬学雑誌,1941年,Vol. 61, No. 7,292-298
J. Org. Chem.,1976年,Vol. 41, No. 22,3540-3545
J. Med. Chem.,2007年,Vol. 50,1886-1895
J. Med. Chem.,2010年,Vol. 53,3465-3479
Bioorg. Med. Chem.,2008年,16,1784-1795
J. Med. Chem.,2010年,53,5267-5280
Bioorg. Med. Chem. Lett.,2016年,26,4599-4605
Bioorganic & Medicinal Chemistry,2017年,25,3606-3613
J. Med. Chem.,2011年,54,5395-5402
Bioorg. Med. Chem. Lett.,2003年,13,3423-3427
Journal of Chromatography B,2004年,801,229-235
Attorney, Agent or Firm:
Nagoya International Patent Attorney Corporation