BENZIMIDAZOLE DERIVATIVE, AND USE THEREOF AS KDR KINASE PROTEIN INHIBITOR

Title:

BENZIMIDAZOLE DERIVATIVE, AND USE THEREOF AS KDR KINASE PROTEIN INHIBITOR

Document Type and Number:

Japanese Patent JP2009167219

Kind Code:

A

Abstract:

To provide pyrazole-benzimidazole derivatives useful for treating or preventing various diseases including cancer as inhibitors of KDR receptors.

Compounds is represented by formula (IAb) [wherein Ab is a substituted pyrazol-3-yl group, and the other substituents A1b, A2b, A3b, A4b, and A5b are as defined in the specification]. The compounds of the formula (IAb) may possibly be isomeric forms including racemates, enantioisomers or diastereoisomers and/or may be any possible adducts of the compounds of formula (IAb) with inorganic acids and organic acids or with inorganic bases and organic bases.

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Inventors:

BABIN DIDIER
LE-BRUN ALAIN
GAUZY-LAZO LAURENCE
BOUCHARD HERVE

Application Number:

JP2009112407A

Publication Date:

July 30, 2009

Filing Date:

May 07, 2009

Export Citation:

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Assignee:

AVENTIS PHARMA SA

International Classes:

C07D403/04; C07D491/056; A61K31/4184; A61K31/4188; A61K31/422; A61K31/4439; A61K31/454; A61K31/496; A61K31/5377; A61P3/00; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D487/04; C07D491/04; C07D491/052; C07D521/00

Attorney, Agent or Firm:

Chika Takagi

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