Title:
CB2受容体リガンドとしてのベンズイミダゾロン誘導体
Document Type and Number:
Japanese Patent JP2008533121
Kind Code:
A
Abstract:
This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis or bronchitis.
Inventors:
Kazuo Ando
Makoto Kawai
Tsutomu Masuda
Hirofumi Omura
Makoto Kawai
Tsutomu Masuda
Hirofumi Omura
Application Number:
JP2008501430A
Publication Date:
August 21, 2008
Filing Date:
March 02, 2006
Export Citation:
Assignee:
Pfizer Japan Inc
International Classes:
C07D235/26; A61K31/4184; A61K31/422; A61K31/4245; A61K31/433; A61K31/437; A61K31/454; A61K31/4725; A61K31/5377; A61K31/541; A61P1/00; A61P1/02; A61P1/08; A61P1/10; A61P1/12; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P11/14; A61P11/16; A61P13/12; A61P17/00; A61P17/04; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P27/06; A61P27/16; A61P29/00; A61P31/18; A61P35/00; A61P37/08; A61P43/00; C07D401/06; C07D403/12; C07D405/06; C07D405/12; C07D413/12; C07D417/12; C07D471/04
Domestic Patent References:
| JPH05194216A | 1993-08-03 |
Foreign References:
| WO2005021539A1 | 2005-03-10 | |||
| US5280028A | 1994-01-18 | |||
| US5300512A | 1994-04-05 | |||
| US5223511A | 1993-06-29 |
Attorney, Agent or Firm:
Yoshinobu Murofushi