To obtain the subject novel compound that has hypoglycemic action and hypolipidemic action and is useful as a hypoglycemic agent and a hypolipidemic agent for treatment of diabetes, hyperlipemia and the like.
This novel compound is a benzisoxazol derivative represented by the formula (A is an aryl or a heterocyclic ring group which may be substituted; B is carboxyl, cyano, a 2-7C alkoxycarbonyl; Y1 is a (substituted) 1-8C alkylene; Y2 is a (substituted) 1-8C alkylene; X1 is a bond, O-atom, S-atom; X2 is a bond, O-atom, S-atom) or its salt, typically 5-[[3-[2-(2-pyridyl)ethyl]-1,2- benzisoxazol-6-yl]methyl]-2,4-thiazolidine dione. The compound of formula I is prepared by subjecting an appropriate aminobenzisoxazole derivative to the Meerwein reaction, by allowing a thiol of the formula: R11SH (R11 is phenyl) to react with the product of the Meerwein reaction followed by hydrolysis of the resultant derivative.
SAKUMA SHOGO
MASUI SEIICHIRO
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